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SaMD pathwayU.S. FDA Market EntrySource review as of 2026-06-10

SaMD FDA Regulatory Pathway Prep: CDS, Cybersecurity, and QMSR

For health software, the first FDA pathway question is not '510(k) or De Novo?' It is whether the specific software function meets the device definition, whether any Non-Device CDS criteria may apply, and what evidence qualified reviewers need before they discuss a submission path.

As of 2026-06-10, the source packet should use FDA's January 2026 CDS guidance, device-software guidance, premarket software guidance, current cybersecurity guidance, QMSR context, and current MDUFA fee references. TrueMedDevice can organize that packet; it does not decide the pathway.

For health-software founders, product leads, and first RA/QA owners who need to brief a consultant on SaMD scope, CDS boundaries, cybersecurity, QMSR, and possible FDA submission questions.

Pre-production brief

FieldDefinition
RoleHealth-software founder, product lead, or first RA/QA owner preparing SaMD review.
ScenarioA software feature may be regulated and the team needs to sort scope, CDS, cybersecurity, QMSR, and submission questions before consultant review.
Concrete problemThe team is jumping to pathway names before documenting the actual software function and source-backed boundaries.
Useful outputA SaMD review packet with function map, CDS worksheet, software evidence checklist, cybersecurity prompts, QMSR context, and open questions.
TrueMedDevice roleOrganize current FDA public guidance and review artifacts without determining device status, pathway, CDS status, cybersecurity adequacy, or compliance.

Start with the function, not the platform

FDA's software guidance is function-focused. A cloud platform, mobile app, dashboard, model, or integration layer does not answer the pathway question by itself.

The packet should describe the software function in plain terms: who uses it, what input it receives, what output it provides, what decision it supports, and what the user is expected to do with the output.

Map Non-Device CDS criteria carefully

FDA's current CDS guidance should be applied to the function, not to the product name. A CDS-like function must be mapped against the statutory criteria, including whether it displays, analyzes, or prints medical information; supports or provides recommendations to a health care professional; and enables independent review of the basis for the recommendation.

If the function is patient-facing, hides the basis for the recommendation, analyzes signals or patterns from medical images or devices, or drives a decision the user cannot independently review, the packet should flag unresolved review questions instead of calling it Non-Device CDS.

Cybersecurity is a submission-evidence workstream

For connected SaMD or software with cybersecurity risk, FDA's current cybersecurity guidance should be part of the evidence map. The useful question is not whether a generic security checklist exists; it is whether the submission packet can show the risk-management, SBOM, vulnerability, testing, labeling, and maintenance evidence that qualified reviewers expect to see.

Do not claim that having an SBOM, threat model, or vulnerability process makes the software acceptable. Treat each as an artifact to review.

QMSR is already in effect

For device manufacturers, QMSR is not a future issue as of this article date. FDA's QMSR page states the rule became the inspection framework on February 2, 2026, alongside the new inspection process.

For a software company, this means the pathway packet should also ask how requirements, design controls, risk management, release control, complaints, CAPA, suppliers, and cybersecurity maintenance will live inside the quality system.

What TrueMedDevice can prepare

TrueMedDevice can prepare a SaMD review packet: function map, current FDA source ledger, CDS criteria worksheet, software documentation checklist, cybersecurity evidence prompt list, QMSR context note, fee-source links, and consultant handoff questions.

Qualified RA/QA, FDA-facing consultants, cybersecurity reviewers, legal counsel, and FDA remain responsible for product-specific device status, pathway, CDS, cybersecurity, QMSR, and submission judgments.

Source ledger

FDA, Clinical Decision Support Software

What it can tell you

FDA's current final CDS guidance and Non-Device CDS criteria.

What it cannot decide

Whether a specific software function is Non-Device CDS or a regulated device function.

FDA, Policy for Device Software Functions and Mobile Medical Applications

What it can tell you

FDA's policy guidance for device software functions and mobile medical applications.

What it cannot decide

Whether a specific product claim or software feature is inside or outside active FDA oversight.

FDA, Content of Premarket Submissions for Device Software Functions

What it can tell you

FDA's recommended software documentation for premarket submissions.

What it cannot decide

The final documentation sufficiency for a specific SaMD submission.

FDA, Cybersecurity in Medical Devices: Quality Management System Considerations and Content of Premarket Submissions

What it can tell you

FDA's current recommendations for cybersecurity documentation in premarket submissions for devices with cybersecurity risk.

What it cannot decide

Whether a specific threat model, SBOM, vulnerability process, or security test plan is sufficient.

FDA, Quality Management System Regulation (QMSR)

What it can tell you

FDA's QMSR overview and effective-date context for device manufacturers.

What it cannot decide

Whether a software company's QMS is compliant.

FDA, Marketing Submission Recommendations for a Predetermined Change Control Plan for Artificial Intelligence-Enabled Device Software Functions

What it can tell you

FDA's final PCCP recommendations for planned modifications to AI-enabled device software functions.

What it cannot decide

Whether a specific SaMD should include a PCCP.

FDA, Medical Device User Fee Amendments (MDUFA): Fees

What it can tell you

Current device user-fee tables for planning context.

What it cannot decide

The submission path, review timing, or small-business eligibility for a specific product.

Frequently asked questions

Does this page decide whether my software is a medical device?

No. It helps describe the software function and map current FDA guidance so qualified reviewers can evaluate the question.

What changed in the CDS discussion?

FDA's current CDS guidance is January 2026. A current packet should use that guidance rather than stale 2022-only framing.

Does cybersecurity documentation apply to every SaMD?

The article does not decide that. It helps identify when cybersecurity risk and FDA cybersecurity guidance should be part of the review packet.

Need a SaMD pathway packet before the consultant call?

TrueMedDevice can organize your software-function, CDS, cybersecurity, QMSR, source-ledger, and open pathway questions into one review packet.